Thursday, August 3, 2023

Fragile Data Requires High Statistical Caution

In this letter to the editor, I point out how the conclusions from a research article published in JAMA is highly questionable and in my opinion basically just speculation given the high statistical fragility and other uncertainties in the methodology. 

Unfortunately, the authors did not respond to the critical issues raised about the validity of their research conclusions. 

Citation: Heston TF. Fragile Data Requires High Statistical Caution [Internet]. 2019 July 19 [cited 2023 July 06]. In: Lloyd M, Karahalios A, Janus E, metal. Effectiveness of a Bundled Intervention Including Adjunctive Corticosteroids on Outcomes of Hospitalized Patients With Community-Acquired Pneumonia: A Stepped-Wedge Randomized Clinical Trial. JAMA Intern Med. 2019;179(8):1052–1060. doi:10.1001/jamainternmed.2019.1438 Available from:

(to see my comments, click on the "comments" tab on the page)

Here is a direct link to my comments:

Citation: Heston, Thomas F. (2019). Fragile Data Requires High Statistical Caution.

Here's a screen capture: