ChatGPT offers interactive learning and access to extensive medical knowledge, benefiting students. However, misinformation risks, cheating, and reduced human interaction are concerns. Guidance from educators, curated content, and reinforcement of critical thinking skills can maximize benefits while minimizing risks. Small group learning maintains interpersonal abilities alongside ChatGPT use. Responsible integration, upholding academic integrity, and preserving humanistic medicine allows the realization of ChatGPT’s potential in medical education.